Immunogenetics of Hashimoto's thyroiditis

doi:10.1186/1740-2557-2-1

Journal of Autoimmune Diseases

Volume 2

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Review

Immunogenetics of Hashimoto's thyroiditis

Dimitry A Chistiakov

Laboratory of Aquatic Ecology, Katholieke Universiteit Leuven, Ch. De Beriotstraat 32, B-3000 Leuven, Belgium

Journal of Autoimmune Diseases 2005, 2:1doi:10.1186/1740-2557-2-1


Published:	11 March 2005

Abstract

Hashimoto's thyroiditis (HT) is an organ-specific T-cell mediated disease. It is a complex disease, with a strong genetic component. To date, significant progress has been made towards the identification and functional characterization of HT susceptibility genes. In this review, we will summarize the recent advances in our understanding of the genetic input to the pathogenesis of HT.