Email updates

Keep up to date with the latest news and content from JAD and BioMed Central.

Open Access Highly Accessed Research

Co-occurrence of autoimmune thyroid disease in a multiple sclerosis cohort

JS Sloka1*, Pryse-WEM Phillips1, M Stefanelli1 and C Joyce2

Author Affiliations

1 Department of Neurology, Memorial University of Newfoundland, St John's, Canada

2 Department of Endocrinology, Memorial University of Newfoundland, St John's, Canada

For all author emails, please log on.

Journal of Autoimmune Diseases 2005, 2:9  doi:10.1186/1740-2557-2-9

Published: 9 November 2005

Abstract

Background

Multiple sclerosis (MS), Hashimoto's disease and Graves' disease are autoimmune diseases that may share similar pathogenic mechanisms. The co-occurrence rates and demographic characteristics of Graves' disease and Hashimoto's disease (HT) in our MS population are compared with the general population.

Methods

The prevalence of thyroid disease in our MS patients was determined by chart review and survey. Previous diagnosis of thyroid disease, age at diagnosis, treatment used, and about the use of disease modifying medications used to treat their MS were asked. Chart reviews were used to estimate the population prevalence of Graves' disease and Hashimoto's disease and to estimate the demographics of patients with thyroid disease.

Results

A significant co-occurrence of Graves' disease with MS (p = 0.002), and a non-significant co-occurrence of Hashimoto's disease were noted (p = 0.097). No difference in the age of onset or gender of thyroid disease in MS patients compared to the general population was found.

Conclusion

There is a significant co-occurrence in patients with MS and Graves' disease, and a trend to co-occurrence in patients with MS and Hashimoto's disease. There are no differences in the demographics of patients with thyroid disease in our MS patients compared to the general population.