|
Comparisons of the parameters of the IAHG scoring system between patients with chronic liver diseases* achieving a probable (n = 8) and a negative AIH score (n = 415). |
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| Characteristics |
Negative score no. of patients (%) |
Probable score no. of patients (%) |
P-value |
|
|
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| Gender |
|||
| Female |
225 (54.2) |
6 (75) |
NS |
| Male |
190 (45.8) |
2 (25) |
|
| ALP/ALT ratio |
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| Positive: score +2 |
330 (79.5) |
8(100) |
NS |
| Negative: score 0, -2 |
85 (20.5) |
0 |
|
| Serum globulin or IgG above normal |
|||
| Positive (score ≥ 1) |
196 (47.2) |
6 (75) |
NS |
| Negative (score 0) |
505 (57.9) |
2 (25) |
|
| ANA, SMA or anti-LKM |
|||
| Positive (titre ≥ 1:40) |
327 (78.8) |
8 (100) |
NS |
| Negative |
88 (21.2) |
0 |
|
| AMA |
|||
| Positive (titre ≥ 1:40) |
48 (11.6) |
1 (12.5) |
NS |
| Negative |
367 (88.4) |
7 (87.5) |
|
| Hepatitis viral markers |
|||
| Yes |
214 (51.6) |
2 (25) |
NS |
| No |
201 (48.4) |
6 (75) |
|
| History of illicit drug use |
|||
| Yes |
25 (6) |
0 |
NS |
| No |
390 (94) |
8 (100) |
|
| Average alcohol intake |
|||
| <25 g/day |
318 (76.6) |
7 (87.5) |
NS |
| >60 g/day |
97 (23.4) |
1 (12.5) |
|
| Histological score |
|||
| Positive (score > 0) |
54 (13) |
4 (50) |
0.015** |
| Negative (score ≤ 0) |
361 (87) |
4 (50) |
|
| Aggregate histological score (mean ± SD) |
-4.13 ± 3.3 |
0.88 ± 2.8 |
<0.001*** |
| Other autoimmune disease |
|||
| Yes |
23 (5.5) |
1 (12.5) |
NS |
| No |
392 (94.5) |
7 (87.5) |
|
| Aggregate AIH score (mean ± SD) |
2.29 ± 4.07 |
11.63 ± 1.19 |
<0.001*** |
|
Abbreviations are same as in text; NS: not statistically significant; SD: standard deviation; *Excluding AIH patients (n = 43) and patients with coincidence of AIH and any kind of liver disorder (n = 24); **Fisher's exact test; ***Mann-Whitney U test; | |||
Papamichalis et al. Journal of Autoimmune Diseases 2007 4:3 doi:10.1186/1740-2557-4-3 |
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