|
Comparisons of the parameters of the IAHG scoring system among patients with chronic liver diseases* (n = 423), AIH/overlap syndromes (n = 10) and patients with coincidence of AIH and other liver disease (n = 14). |
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| Characteristics |
Patients with liver diseases* no. of patients (%) |
Patients with AIH/overlap syndromes no. of patients (%) |
Patients with coincidence of AIH and other liver disease no. of patients (%) |
P value |
|
|
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| Gender |
||||
| Female |
231 (54.6) |
5 (50) |
7 (50) |
NS |
| Male |
192 (45.4) |
5 (50) |
7 (50) |
|
| ALP/ALT ratio |
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| Positive: score +2 |
338 (79.9) |
8 (80) |
12 (85.7) |
NS |
| Negative: score 0, -2 |
85 (20.1) |
2 (20) |
2 (14.3) |
|
| Serum globulin or IgG above normal |
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| Positive (score ≥ 1) |
202 (47.8) |
7 (70) |
10 (71.4) |
NS |
| Negative (score 0) |
221 (52.2) |
3 (30) |
4 (28.6) |
|
| ANA, SMA or anti-LKM |
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| Positive (titre ≥ 1:40) |
335 (79.2) |
9 (90) |
14(100) |
NS |
| Negative |
88 (20.2) |
1 (10) |
0 |
|
| AMA |
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| Positive (titre ≥ 1:40) |
49 (11.6) |
4 (40) |
0 |
0.009** |
| Negative |
374 (88.4) |
6 (60) |
14(100) |
|
| Hepatitis viral markers |
||||
| Yes |
216 (51.1) |
0 |
8 (57.1) |
0.005** |
| No |
207 (48.9) |
10 (100) |
6 (42.9) |
|
| History of illicit drug use |
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| Yes |
25 (5.9) |
0 |
0 |
NS |
| No |
398 (94.1) |
10 (100) |
14 (100) |
|
| Average alcohol intake |
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| <25 g/day |
325 (76.8) |
10 (100) |
11 (78.6) |
0.013** |
| >60 g/day |
98 (23.2) |
0 |
3 (21.4) |
|
| Histological score |
||||
| Positive (score > 0) |
58 (13.7) |
3 (30) |
10 (71.4) |
<0.001** |
| Negative (score ≤ 0) |
365 (86.3) |
7 (70) |
4 (28.6) |
|
| Aggregate histological score (mean ± SD) |
-4± 3.3 |
-2.1± 4.4 |
2.14± 1.7 |
<0.001*** |
| Other autoimmune disease |
||||
| Yes |
24 (5.7) |
5 (50) |
2 (14.3) |
<0.001** |
| No |
399 (94.3) |
5 (50) |
12 (85.7) |
|
| Aggregate AIH score (mean ± SD) |
2.5 ± 4.23 |
9.3 ± 4.8 |
10.5 ± 3.7 |
<0.001*** |
|
Abbreviations are same as in text; NS: not statistically significant; SD: standard deviation; *Excluding AIH patients (n = 43) and patients with coincidence of AIH and any kind of liver disorder (n = 24); **Total x square (comparison amongst the three groups of patients; for statistical significance between groups see text of results; subheading Comparison between groups, second paragraph); ***Kruskal-Wallis test (comparison amongst the three groups of patients; for statistical significance between groups see text of results, subheading Comparison between groups, second paragraph). | ||||
Papamichalis et al. Journal of Autoimmune Diseases 2007 4:3 doi:10.1186/1740-2557-4-3 |
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